Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies
نویسندگان
چکیده
منابع مشابه
Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies
Serum immunoglobulin (Ig)M provides the initial response to foreign antigen and plays a regulatory role in subsequent immune response development, accelerating the production of high-affinity IgG. Here we show that mice deficient in serum IgM have an increased propensity to spontaneous autoimmunity as judged by the development with age of serum IgG anti-DNA antibodies and the renal deposition o...
متن کاملAccelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM.
Individuals with systemic lupus erythematosus and rheumatoid arthritis are characterized by the presence of high levels of circulating IgM and IgG autoantibodies. Although IgG autoantibodies often are pathogenic, the role of IgM autoantibodies in autoimmune disease is not clear. Using mice that are unable to secrete IgM but are able to express surface IgM and IgD and to secrete other classes of...
متن کاملProduction of immunoglobulin M (IgM) autoantibodies to IgG in rabbits inoculated with Mycoplasma salivarium cells grown in medium supplemented with rabbit serum.
Mycoplasma salivarium cells propagated in PPLO broth (Difco Laboratories, Detroit, Mich.) supplemented with rabbit serum (10% [vol/vol]) and harvested by centrifugation were shown to contain rabbit immunoglobulin G (IgG) (approximately 4 to 10% of total cell proteins) and to produce IgM autoantibodies to IgG when inoculated into rabbits.
متن کاملImmunoglobulin IgG, IgM, IgA, and IgE Levels in Children with Chronic Sinusitis
Background and purpose: Sinusitis is a common disease in children that can lead to acute and chronic problems and sometimes severe complications. There is lack of evidence on underlying causes of chronic sinusitis in children in Iran, so, this study aimed to investigate the prevalence of humoral immune deficiency in patients with chronic sinusitis. Materials and methods: This cross-sectional s...
متن کاملSerum immunoglobulin concentrations in preschool children measured by laser nephelometry: reference ranges for IgG, IgA, IgM.
Serum immunoglobulin concentrations were determined on sera from 298 healthy children aged six months to six years using the Hyland laser nephelometer PDQ system. Age-specific 95% reference ranges for serum IgG, IgA and IgM are presented; considerable care has been taken to ensure statistical validity of the reference ranges. The wide range of values in children under two years suggest that mea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2000
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.191.7.1253